Pittsburgh Steelers (4–2) vs. New Orleans Saints (2–4)
9:30 a.m. | NFL Network | Paris, France
Odds: Pittsburgh -3 | Total: 44.5

QB matchup: Aaron Rodgers has 1,487 passing yards, 12 touchdowns and five interceptions. Tyler Shough has 1,443 yards, 12 touchdowns and five interceptions. Rodgers has thrown 11 of his touchdowns over the past four games.  

Offense/Defense: Pittsburgh averages 320.5 offensive yards per game/allows 307.5 yards; New Orleans 321.5 offensive yards per game/allows 377.7. Pittsburgh’s rushing attack faces a Saints defense allowing 138 rushing yards per game.  

Key injuries: Pittsburgh RB Rico Dowdle (knee) and S DeShon Elliott (knee) are questionable; CB Brandin Echols (hamstring) and WR Ben Skowronek (calf) are out.   New Orleans G Cesar Ruiz (knee) and DL Nathan Shepherd (illness) are questionable. RB Alvin Kamara practiced on a limited basis but has no game designation.  

Last three games:

• Pittsburgh: Won 26–19 at Tampa Bay, covered; won 34–22 vs. Indianapolis, covered; lost 27–24 at Cleveland, failed to cover.
• New Orleans: Won 34–27 at the Giants, covered; lost 23–13 vs. Minnesota, failed to cover; lost 45–24 vs. Atlanta, failed to cover.

Last-game recap: Rodgers completed 33 of 49 passes for 253 yards, two touchdowns and one interception in Pittsburgh’s win. New Orleans snapped a three-game losing streak against the Giants, building a large lead before surviving a late comeback.  

Weather: Approximately 59°F, partly cloudy, with west winds near 19 mph. 

Matchup read: Pittsburgh has an opportunity to establish the run against a vulnerable front. New Orleans needs protection for Shough and productive early downs to avoid obvious passing situations.

Cincinnati Bengals (3–2) at Baltimore Ravens (4–2)
1 p.m. | CBS
Odds: Baltimore -1 | Total: 48.5

QB matchup: Joe Burrow has completed 71.4% of his passes for 1,361 yards, 11 touchdowns and three interceptions. Lamar Jackson has 967 yards, six touchdowns and one interception, but his availability remains uncertain due to a high  anknle sprain. Backup Tyler Huntley has 429 yards, three touchdowns and no interceptions. 

Offense/Defense: Cincinnati averages 342.8 per game offensively/allows 344.2 yards; Baltimore averages 367.7 yards per game/allows 310.8 yards per game. Baltimore’s 151.5 rushing yards per game give it a different offensive profile from Cincinnati’s pass-oriented attack.  

Key injuries: Jackson is questionable with an ankle injury after limited practices all week. Baltimore S Jaylinn Hawkins (knee) and OLB Tavius Robinson (pectoral) are out; CB T.J. Tampa (knee) is doubtful and DT Broderick Washington (ankle) questionable.  

Last three games:

• Cincinnati: Won 31–24 at Miami, covered; lost 22–17 vs. Jacksonville, failed to cover; lost 30–27 at Pittsburgh, failed to cover.
• Baltimore: Lost 13–10 at Cleveland, failed to cover; won 30–23 at Atlanta, covered; won 24–18 vs. Tennessee, failed to cover.

Last-game recap: Cincinnati entered its bye following a seven-point win at Miami. Baltimore managed only 10 points at Cleveland; a fourth-quarter Derrick Henry fumble helped set up the Browns’ only touchdown before Cleveland won on a late field goal.  

2025 matchups: Cincinnati won 32–14 at Baltimore, covering as a 7.5-point underdog. Baltimore won the return meeting 24–0, covering -3. Both games stayed under 52.5.  

Weather: About 61°F, clear, winds around 3 mph.  

Cleveland Browns (4–2) at Tennessee Titans (1–5)
1 p.m. | CBS
Odds: Cleveland -2 | Total: 37

QB matchup: Deshaun Watson: 63.8%, 1,174 yards, seven touchdowns, two interceptions. Cam Ward: 61.6%, 998 yards, four touchdowns, four interceptions 

Offense/Defense: Cleveland averages 267.5 yards per game/allows 317.5 yards; Tennessee averages 236.3 yards per game /allows 343.0 yards per game. Both offenses rank near the bottom in total production.  

Key injuries: Cleveland DTs Kalia Davis (quad) and Mike Hall Jr. (ankle), G Teven Jenkins and backup QB Dillon Gabriel are out. CB Denzel Ward is questionable with a hand injury. Tennessee WR Calvin Ridley (hip), RB Tyjae Spears (knee) and S Tony Adams (ankle) are questionable. 

Last three games:

• Cleveland: Won 13–10 vs. Baltimore, covered; lost 17–12 at the Jets, failed to cover; won 27–24 vs. Pittsburgh, covered.
• Tennessee: Won 26–20 at Indianapolis, covered; lost 26–3 vs. Houston, failed to cover; lost 24–18 at Baltimore, covered.

Last-game recap: Watson threw for 164 yards without a touchdown but directed Cleveland’s winning drive, capped by Andre Szmyt’s 37-yard field goal. Tennessee earned its first victory despite Ward throwing for only 102 yards, benefiting from three takeaways and important special-teams plays.  

2025 matchup: Tennessee won 31–29 at Cleveland.  

Weather: Approximately 72°F, clear, winds near 3 mph.  

Indianapolis Colts (2–4) at Minnesota Vikings (5–0)
1 p.m. | CBS
Odds: Minnesota -6.5 | Total: 41.5

QB matchup: Daniel Jones has 1,290 yards, four touchdowns and six interceptions. Kyler Murray has 662 yards, two touchdowns and two interceptions in his playing time this season. 

Offense/Defense: Indianapolis averages 311.3 yards per game/allows 351.2 yards per game; Minnesota averages 283.0 yards per game/allows 259.8 yards per game. Minnesota has allowed only 12.8 points per game. 

Key injuries: Indianapolis TE Tyler Warren (groin), CB Sauce Gardner (calf) and WR Anthony Gould (concussion) are out. Minnesota expects LT Christian Darrisaw, TE T.J. Hockenson and WR Jordan Addison back; RB Jordan Mason (thumb) is questionable and requires activation from injured reserve. 

Last three games:

• Indianapolis: Lost 26–20 vs. Tennessee, failed to cover; lost 34–22 at Pittsburgh, failed to cover; won 30–13 at Washington, covered.
• Minnesota: Won 23–13 at New Orleans, covered; won 15–10 vs. Miami, failed to cover; won 23–16 at Tampa Bay, covered.

Last-game recap: Jones threw for 269 yards with one touchdown and two interceptions as Indianapolis squandered a 13–0 halftime lead against Tennessee. Before its bye, Minnesota beat New Orleans behind Murray’s 24-of-30 passing for 229 yards and a touchdown.

2025 matchup: None. Minnesota won the previous meeting 21–13 in November 2024.  

Weather: Indoors at U.S. Bank Stadium.

Miami Dolphins (0–5) at New York Jets (2–4)
1 p.m. | CBS
Odds: Jets -4.5 | Total: 38.5

QB matchup: Malik Willis: 56.2%, 849 yards, two touchdowns, four interceptions. Geno Smith: 68.9%, 1,336 yards, seven touchdowns, one interception.  

Offense/Defense: Miami averages 280.2 yards per game/allows 329.8 yards; New York averages 290.7 yards per game/allows 308.0. The Jets allow only 185 net passing yards per game, a difficult matchup for Miami’s struggling passing attack.  

Key injuries: Jets RB Breece Hall (quad) and G Dylan Parham (knee) are questionable; EDGE Joseph Ossai (ankle), OL Max Mitchell (concussion) and LB Kiko Mauigoa (quad) are out. WR Adonai Mitchell is cleared to return. Miami CB Reese Taylor (quad) is out; EDGE Rob Beal Jr. (hamstring) is doubtful. Willis practiced fully despite a thumb issue.  

Last three games:

• Miami: Lost 31–24 vs. Cincinnati, failed to cover; lost 15–10 at Minnesota, covered; lost 24–10 vs. Kansas City, failed to cover.
• Jets: Lost 26–19 at New England, covered; won 17–12 vs. Cleveland, covered; lost 23–12 at Chicago, failed to cover.

Last-game recap: Miami rushed for 217 yards against Cincinnati, but Willis threw two interceptions. The Jets lost at New England despite Smith’s 252 passing yards and rookie Omar Cooper Jr.’s six catches for 103 yards and a touchdown.  

2025 matchups: Miami swept 27–21 at home and 34–10 on the road, covering -2.5 both times. Both went over.  

Weather: Around 63°F, clear, west winds near 3 mph.  

New York Giants (3–2–1) at Houston Texans (2–4)
1 p.m. | FOX
Odds: Houston -10 | Total: 42.5

QB matchup: J.J. McCarthy makes his first Giants start after throwing for 243 yards, one touchdown and one interception in relief last week. C.J. Stroud: 65.3%, 1,714 yards, nine touchdowns, one interception.  

Offense/Defense: New York averages 333.7 yards per game/allows 325.7 yards; Houston averages 355.0 yards per game/allows 329.0 yards per game. Houston permits just 83 rushing yards per game.  

Key injuries: Giants LB Tremaine Edmunds (shoulder) and CB Greg Newsome II (concussion) are out; TE Theo Johnson (neck) is doubtful. CB Paulson Adebo, S Jevón Holland and OT Jermaine Eluemunor are questionable. Houston RB David Montgomery (groin), safeties Jalen Pitre and Reed Blankenship, and OT Blake Fisher are out. WR Tank Dell is questionable. 

Last three games:

• Giants: Lost 34–27 vs. New Orleans, failed to cover; tied 27–27 at Washington, covered; won 36–24 vs. Arizona, covered.
• Houston: Won 34–31 at Jacksonville, covered; won 26–3 at Tennessee, covered; lost 34–30 vs. Dallas, failed to cover.

Last-game recap: McCarthy sparked three late scoring drives after replacing Jameis Winston, but New York’s comeback fell short. Stroud threw for 312 yards and three touchdowns as Houston won its second straight game.  

Weather: Houston’s outdoor forecast is about 78°F, partly cloudy. Roof status determines exposure at the retractable-roof stadium.  

San Francisco 49ers (6–0) at Atlanta Falcons (2–4)
1 p.m. | FOX
Odds: San Francisco -2.5 | Total: 49.5

QB matchup: Brock Purdy: 69.6%, 1,460 yards, 14 touchdowns, two interceptions. Michael Penix Jr.: 64.5%, 944 yards, six touchdowns, one interception.  

Offense/Defense: San Francisco averages 366.7 yards per game/allows 300.0 yards per game; Atlanta averages 344.3 yards per game/allows 335.2 yards per game. Atlanta has been stronger against the run than the pass.  

Key injuries: Atlanta RB Brian Robinson (hamstring), LB Divine Deablo (forearm), DB Billy Bowman Jr. (hamstring) and OT Michael Jerrell (biceps) are out. CBs A.J. Terrell Jr. and C.J. Henderson are questionable. San Francisco’  DE Nick Bosa, WRs Mike Evans and Deebo Samuel, and CB Upton Stout did not practice on Thursday. Evans and Samuel are out. Bosa could play.

Last three games:

• San Francisco: Won 23–17 vs. Washington, failed to cover; won 32–29 at Seattle, covered; won 24–14 vs. Denver, covered.
• Atlanta: Lost 31–23 vs. Chicago, failed to cover; lost 30–23 vs. Baltimore, failed to cover; won 45–24 at New Orleans, covered.

Last-game recap: San Francisco remained unbeaten with a six-point Monday-night victory. Atlanta lost its second straight home game despite Penix throwing for 225 yards and three touchdowns without an interception. 

2025 matchup: San Francisco won 20–10 at home, covering as a 1.5-point underdog; the game stayed under 46.5. 

Weather: Around 64°F outside; check the retractable-roof decision.  

Tampa Bay Buccaneers (1–5) at Carolina Panthers (3–2)
1 p.m. | FOX
Odds: Carolina -2.5 | Total: 44.5

QB matchup: Baker Mayfield is expected back but officially questionable: 63.5%, 615 yards, two touchdowns, two interceptions. Backup Jalon Daniels has 501 yards, three touchdowns and five interceptions. Bryce Young: 60.2%, 1,549 yards, 11 touchdowns, two interceptions. 

Offense/Defense: Tampa Bay averages 292.7 yards per game/allows 299.5 yards per game; Carolina averages 404.4 yards per game/allows 354.2 yards per game. Carolina’s productive passing offense faces a Tampa Bay defense allowing only 75.5 rushing yards per game.  

Key injuries: Tampa Bay WR Emeka Egbuka (concussion/foot), RT Luke Goedeke (calf) and S Antoine Winfield Jr. (rib) are out. Mayfield’s injury is to his throwing-hand thumb. Carolina OLB Jaelan Phillips (hamstring) is out; OT Monroe Freeling (knee) is questionable. Young practiced fully despite a knee issue. 

Last three games:

• Tampa Bay: Lost 26–19 vs. Pittsburgh, failed to cover; won 24–16 at Dallas, covered; lost 17–14 vs. Green Bay, failed to cover.
• Carolina: Won 25–14 at Philadelphia, covered; won 32–26 vs. Detroit, covered; lost 21–18 at Cleveland, failed to cover.

Last-game recap: Daniels threw for 164 yards with one touchdown and two interceptions against Pittsburgh. Young threw for 281 yards and two touchdowns without an interception in Carolina’s win at Philadelphia.  

2025-season matchups: Carolina won 23–20 on December 21; Tampa Bay won 16–14 on January 3, 2026. Carolina covered both, and both stayed under.  

Weather: About 64°F, clear, northeast winds near 12 mph.  

Denver Broncos (4–2) at Arizona Cardinals (2–4)
4:05 p.m. | CBS
Odds: Denver -4.5 | Total: 43.5

QB matchup: Bo Nix: 60.3%, 1,049 yards, six touchdowns, three interceptions. Jacoby Brissett: 66.7%, 1,328 yards, nine touchdowns, six interceptions.  

Offense/Defense: Denver averages 252.2 yards per game/allows 348.3 yards; Arizona averages 307.3 yards per game/allowed 350.5 yards per game. Denver’s offense averages just 4.5 yards per play, while Arizona’s defense allows 6.3. 

Key injuries — latest verified team reports are Thursday: Denver CB Pat Surtain II (ankle) and WR Jaylen Waddle (chest) were limited; S Talanoa Hufanga and OLB Jonah Elliss missed practice with ankle injuries. Arizona S Budda Baker (groin/illness), CB Max Melton (knee), DL Walter Nolen III (ankle) and RB Jeremiyah Love (ankle) did not practice.  

Last three games:

• Denver: Won 17–14 vs. Seattle, covered; won 23–17 at the Chargers, covered; lost 24–14 at San Francisco, failed to cover.
• Arizona: Won 18–16 at the Rams, covered; lost 45–21 vs. Detroit, failed to cover; lost 36–24 at the Giants, failed to cover.

Last-game recap: Denver beat Seattle despite Nix throwing for only 107 yards, benefiting from two Darnold interceptions. Arizona ended a four-game losing streak with an upset of the Rams as a 13.5-point underdog.  

Weather: Approximately 78°F outside, light winds; retractable-roof status remains relevant. 

Green Bay Packers (4–2) at Detroit Lions (3–2)
4:25 p.m. | FOX
Odds: Detroit -3 | Total: 53.5

QB matchup: Jordan Love: 59.7%, 1,684 yards, 11 touchdowns, four interceptions. Jared Goff: 67.0%, 1,485 yards, 12 touchdowns, no interceptions.  

Offense/Defense: Green Bay averages 329.2 yards per game/allows 307.7 yards per game; Detroit averages 393.8 yards per game/allows 404.4 yards per game. Green Bay’s rushing offense averages only 59.8 yards, but Detroit allows 297.4 net passing yards per game.  

Key injuries: Green Bay LB Zaire Franklin (shin) is out, joining the already sidelined Edgerrin Cooper. G Aaron Banks (knee/toe) and CB Benjamin St-Juste (hamstring) are questionable. Detroit C Cade Mays and S Brian Branch are questionable.  

Last three games:

• Green Bay: Won 23–13 vs. Dallas, covered; won 31–7 vs. Chicago, covered; won 17–14 at Tampa Bay, covered.
• Detroit: Won 45–21 at Arizona, covered; lost 32–26 at Carolina, failed to cover; won 31–24 vs. the Jets, covered.

Last-game recap: Love threw for 276 yards and a touchdown as Green Bay won its third straight. Before its bye, Detroit scored 45 at Arizona, with Goff throwing three touchdowns and no interceptions.  

2025 matchups: Green Bay swept 27–13 at home and 31–24 at Detroit, covering both. The first stayed under; the second went over.  

Weather: Indoors at Ford Field.

Los Angeles Rams (2–4) at Las Vegas Raiders (3–3)
4:25 p.m. | FOX
Odds: Rams -3.5 | Total: 48.5

QB matchup: Matthew Stafford: 65.9%, 1,794 yards, 11 touchdowns, six interceptions. Kirk Cousins: 63.4%, 1,582 yards, 14 touchdowns, five interceptions. 

Offense/Defense: Los Angeles averages 401.3 yards per game/allows 294.0 yards; Las Vegas averages 342.7 yards per game/allows 371.7 yards per game. The Rams’ yardage production has been much stronger than their record suggests.  

Key injuries: Rams WR Davante Adams is on injured reserve with a hamstring injury. WR Puka Nacua (calf) and CB Trent McDuffie (groin) are questionable; ILB Nate Landman (concussion) is out. Raiders RB Mike Washington Jr. (foot/back) is questionable.  

Last three games:

• Rams: Lost 18–16 vs. Arizona, failed to cover; lost 37–34 vs. Buffalo, failed to cover; won 24–20 at Philadelphia, covered.
• Raiders: Lost 33–30 vs. Buffalo, covered; lost 45–17 at New England, failed to cover; lost 30–27 vs. Kansas City, covered.

Last-game recap: Stafford completed 25 of 33 passes for 222 yards and two touchdowns, but Los Angeles lost to Arizona. Las Vegas lost another close game against Buffalo after converting only two of five red-zone possessions into touchdowns.  

Weather: Indoors at Allegiant Stadium.

Kansas City Chiefs (5–0) at Seattle Seahawks (3–3)
8:20 p.m. | NBC/Peacock
Odds: Seattle -2.5 | Total: 42.5

QB matchup: Patrick Mahomes: 66.5%, 1,309 yards, nine touchdowns, three interceptions. Sam Darnold: 60.4%, 1,033 yards, seven touchdowns, seven interceptions.  

Offense/Defense: Kansas City averages 414.0 yards per game/allows 306.0 yards per game; Seattle averages 332.2 yards per game/allows 237.3 yards per game. This matches the league’s leading offense in total yardage against its leading defense in yards allowed.  

Key injuries: Kansas City WR Rashee Rice (hamstring/knee), OL Jaylon Moore (concussion) and RB Brashard Smith (hamstring) are out. CB L’Jarius Sneed (knee) is questionable. Mahomes and TE Travis Kelce have no final designation. Seattle:  OLB Uchenna Nwosu (hip) and EDGE DeMarcus Lawrence (knee/rest) were limited; LB Drake Thomas (ankle) did not practice.  

Last three games:

• Kansas City: Won 22–6 vs. the Chargers, covered; won 30–27 at Las Vegas, failed to cover; won 24–10 at Miami, covered.
• Seattle: Lost 17–14 at Denver, failed to cover; lost 32–29 vs. San Francisco, failed to cover; won 30–23 vs. the Chargers, covered.

Last-game recap: Mahomes completed 23 of 30 passes for 272 yards as Kansas City remained unbeaten. Darnold threw for 278 yards but had two interceptions and no touchdown passes in Seattle’s Thursday-night loss at Denver.  

Weather: Approximately 54°F, partly cloudy, winds around 5 mph, with a 38% precipitation chance.