On Thursday, Week 5 of the NFL begins, but Week 6 of the College Football season has begun since Tuesday.  Let’s check out betting previews for: 

Friday, October 9

Florida State at Louisville

7:00 ET • ESPN • Louisville -3.5 | Total 59.5

Florida State 3-2 SU, 2-3 ATS, 1-4 O/U, 1-1 ACC; Louisville 2-3 SU, 3-2 ATS, 4-1 O/U, 1-2 ACC

QB matchup: Ashton Daniels (FSU): 1,111 passing yards, 6 TD, 6 INT. Lincoln Kienholz (Louisville): 1,394 yards, 9 TD, 1 INT; Daniels’ rushing threat is a major part of FSU’s attack.

Last game: Florida State won 38-7 over Virginia Cavaliers. Louisville lost 28-31 to NC State Wolfpack.

Key injuries: Louisville QB Lincoln Kienholz is PROBABLE, upgraded from questionable. FSU DL Darryll Desir is QUESTIONABLE; RB Samuel Singleton Jr., WR Devin Carter and LB Blake Nichelson are OUT. Louisville RB Keyjuan Brown, DB TJ Banks and OL Cason Henry are QUESTIONABLE; OT Bryten Close, OL Sam Secrest and WR Montavin Quisenberry are OUT.

Offense/defense: FSU’s quarterback runs and downhill rushing attack test Louisville’s defensive fits; the Seminoles ran for 281 yards against Virginia. Louisville can answer through Kienholz against FSU’s vulnerable pass coverage. A clean pocket favors the Cardinals, while Daniels’ mobility can neutralize pressure and extend drives.

Key trends: FSU is: 1)5-0 Over last 5 on the road in series. 2)6-1 Under last 7 in October. 3)4-0 Under last 4 after a SU win. 4)0-4 ATS last 4 Friday games. 5)0-4 ATS last 4 after an ATS win. Ville is: 1)5-1 Over last 6 overall. 2)5-1 ATS last 6 after an ATS loss.

Iowa at Washington

9:00 ET • FOX/FS1• Washington -3.5 | Total 41.5

Iowa 4-1 SU, 3-2 ATS, 1-4 O/U, 1-1 B10; Washington 3-2 SU, 1-4 ATS, 2-3 OU, 0-2 B10

QB matchup: Hank Brown/Jeremy Hecklinski (Iowa) vs. Demond Williams Jr. (Washington). Brown: 832 yards, 5 TD, 1 INT, but questionable with a shoulder injury. Hecklinski was 5-of-5 for 67 yards in relief against Ohio State. Williams: 1,327 yards, 8 TD, 3 INT. Iowa’s starter must be confirmed before kickoff.

Key injuries: Iowa QB Hank Brown — QUESTIONABLE, shoulder; S Tyler Brown and DB Kyler Gerardy — OUT; DB Ty Hudkins — QUESTIONABLE.  

Washington CB Jeron Jones — DOUBTFUL, undisclosed. He has started three games, with 19 tackles and an interception. C Landen Hatchett — QUESTIONABLE, wrist. RBs Quaid Carr and Jayden Limar — OUT; S CJ Christian — OUT for the season, Achilles.

Last game: Iowa lost 31-14 to Ohio State Buckeyes. Washington lost 21-25 to USC Trojans.

Key injuries: NEW: Iowa QB Hank Brown is QUESTIONABLE (shoulder); Jeremy Hecklinski may start.   

Offense/defense: Iowa needs to reestablish its ground game after managing only 39 rushing yards against Ohio State. Washington’s passing attack tests Iowa’s zone coverage, but the Hawkeyes can keep this close by limiting explosives and winning field position. A backup start would increase the importance of protection and manageable third downs.

Key trends: IA is: 1)6-0-1 ATS last 7 road games. 2)5-1 Under last 6 conference games. 3)8-1 Over last 9 after an ATS loss. Wash is: 1)3-13 ATS last 16 after an ATS win. 2)5-1 Under last 6 in October. 3)0-4 ATS last 4 home games.

Washington State at Utah State

9:00 ET • The CW • Utah State -5.5 | Total 43.5

Washington State 1-4 SU, 3-2 ATS, 2-3 O/U, 0-1 Pac-12; Utah State 1-4 SU, 3-2 ATS, 1-4 O/U, 0-1 Pac-12.

QB matchup: Caden Pinnick (Washington State): 61.3%, 796 yards, 3 TD, 5 INT; 178 rushing yards. McCae Hillstead (Utah State): 764 yards, 6 TD, 6 INT; 232 rushing yards.

Last game: Washington State lost 6-26 to Fresno State Bulldogs. Utah State lost 18-37 to Boise State Broncos.

2025 matchup: Washington State beat Utah State 34-21 in the Famous Idaho Potato Bowl.

Key injuries: Utah State QB McCae Hillstead is listed PROBABLE.

Offense/defense: Washington State produced only 182 yards against Fresno State, including 30 on the ground. Utah State’s quarterback runs offer a better way to create efficient early downs, but interceptions have repeatedly hurt the Aggies.

Key trends: WST is: 1)7-1 Under last 8 road games. 2)5-1 Over last 6 Friday games. 3)5-1 ATS last 6 after an ATS loss. UTS is: 1)9-2 ATS last 11 home games. 2 )3-0-1 ATS last 4 Friday games. 3)4-1 Under last 5 games overall.

Wyoming at San Jose State

9:00 ET • CBSSN • San Jose State -5.5 | Total 42.5

Wyoming 2-3 SU, 3-2 ATS, 1-4 O/U, 1-0 MWC; San Jose State 3-2 SU, 3-2 ATS, 1-4 O/U, 1-0 MWC

QB matchup: Tyler Hughes (Wyoming): 58.9%, 708 yards, 2 TD, 6 INT; 184 rushing yards. Luke Weaver (San Jose State): 1,278 yards, 11 TD, 5 INT.  

Last game: Wyoming lost 0-28 to North Dakota State Bison. San Jose State won 20-16 over Hawaii Warriors.

Key injuires: Wyoming LB Ethan Stuhlsatz — QUESTIONABLE, ankle. Wyoming’s leading tackler has 39 tackles; CB Ian Bell — QUESTIONABLE, foot. WR Deion DeBlanc — OUT, toe.  

Offense/defense: Wyoming’s passing struggles allow San Jose State to crowd the line and force Hughes or his replacement to win outside. Weaver gives the Spartans the more productive passing option, but Wyoming can slow possessions if it avoids giveaways. SJSU’s own limited rushing production makes sustained pass protection important.

Key trends: Wyo is: 1)0-6 ATS last 6 road games. 2)5-2 ATS last 7 in October. 3)6-0 Under last 6 after a SU loss. 4)6-0 Under last 6 after a SU and ATS loss. SJST is: 1)4-0 Under last 4 games overall. 2)6-0 Under last 6 after an ATS loss. 3)11-4 ATS last 15 Friday games.

Iowa State at BYU

10:15 ET • ESPN • BYU -9.5 | Total 46.5

Iowa State 3-2 SU, 3-2 ATS, 3-2 O/U, 1-1 B12;  BYU 4-0 SU, 4-0 ATS, 2-2 O/U, 2-0 B12

QB matchup: Jaylen Raynor (Iowa State): 903 yards, 6 TD, 4 INT; 152 rushing yards and 3 rushing TD. Bear Bachmeier (BYU): 704 yards, 6 TD, 1 INT; 130 rushing yards and 4 rushing TD. Bachmeier has the cleaner turnover profile.

Last game: Iowa State won 45-42 over West Virginia Mountaineers. BYU won 17-10 over TCU Horned Frogs.

Key injuries: Iowa State RB E. Miller and TE L. Galer are questionable; WR C. Pabst is out for the season. Additional listings: Iowa State TEs C. Greenlaw and R. Barnes are QUESTIONABLE; CB J. Singletary and DL C. Crawford are OUT.  

Offense/defense: Iowa State’s 45-42 win exposed defensive vulnerabilities despite a productive offense. BYU can stress those fits with Bachmeier’s mobility and a balanced attack, while Iowa State needs Raynor to create chunk plays without turnovers. BYU’s 17-10 win over TCU also shows it can win a controlled, lower-possession game.

Key trends: IST is: 1)0-4-1 ATS last 5 games in October. 2)4-0 Under last 4 road games. 3)5-0 Under last 5 games after a DD loss at home. BYU is: 1)4-1 Under last 5 conference games. 2)5-0 ATS last 5 as a home fave. 3)5-0 Under last 5 after scoring more than 40 points in their previous game.